Holland Eric C [a]. Varmus Harold E.
Basic fibroblast growth factor induces cell migration and
proliferation after glia-specific gene transfer in mice, Proceedings of the National Academy of Sciences of the United States of
America 95(3) :1218-1223, 1998.
Abstract
Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade
human gliomas, implying that it is involved in the pathogenesis of these
tumors. To assess the biological effect of inappropriate production of bFGF
in normal astrocytes, we developed a system for
glia-specific gene transfer in transgenic mice. A transgene encoding the
receptor for subgroup A avian leukosis virus and controlled by the
astrocyte-specific glial fibrillary acidic protein promoter
permits efficient glia-specific transfer of genes carried by subgroup A
avian leukosis virus vectors. With this system, we have demonstrated that
bFGF induces proliferation and migration of glial cells in
vivo, without the induction of tumors.
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