Eddershaw Peter J [a]. Beresford Alan P [a]. Bayliss Martin K [a].
ADME/PK as part of a rational approach to drug
discovery, Drug Discovery Today 5(9) :409-414, 2000.
Abstract
Rational drug discovery requires an early
appraisal of all factors impacting on the likely success of a
drug candidate in the subsequent preclinical, clinical and
commercial phases of drug development. The study of
absorption, distribution, metabolism, excretion and pharmacokinetics
(ADME/PK) has developed into a relatively mature discipline in
drug discovery through the application of
well-established in vitro and in vivo methodologies. The availability of
improved analytical and automation technologies has dramatically increased
our ability to dissect out the fundamentals of ADME/PK through the
development of increasingly powerful in silico methods. This
is fuelling a shift away from the traditional, empirical nature of ADME/PK
towards a more rational, in cerebro approach to drug design.
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