Hauss-Wegrzyniak Beatrice. Vannucchi Maria G. Wenk Gary L [a].
Behavioral and ultrastructural changes induced by chronic
neuroinflammation in young rats, Brain Research 859(1) :157-166, 2000.
Abstract
We investigated the ultrastructural, immunohistochemical, biochemical and
behavioral effects of chronic neuroinflammation in young
rats produced by injection of lipopolysaccharide (LPS) into the 4th
ventricle. The 37-day infusion of LPS impaired spatial memory but not object
recognition ability. Electron microscopic studies of neurons within the
hippocampus identified numerous paired cisternae of the rough endoplasmic
reticulum (RER) and other ultrastructural changes that suggested impaired or
reduced synthesis of cellular proteins within the cytoplasm.
Immunohistochemical staining found numerous highly activated microglia
distributed throughout the cingulate gyrus, entorhinal cortex, hippocampus
and dentate gyrus. This animal model may be useful to test potential
pharmacotherapies that are directed at the prevention of the cytotoxic
consequences of chronic neuroinflammation associated with
normal aging or Alzheimer's disease.
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