Hauss-Wegrzyniak Beatrice. Vraniak Peter. Wenk Gary L [a].
The effects of a novel NSAID on chronic neuroinflammation
are age dependent, Neurobiology of Aging 20(3) :305-313, 1999.
Abstract
Chronic inflammation may play an important role in the pathogenesis of
Alzheimer's disease (AD). The present study compared the effects of chronic
neuroinflammation, produced by infusion of
lipopolysaccharide (LPS) into the fourth ventricle, upon memory in young,
adult, and old rats. Nonsteroidal anti-inflammatory drug (NSAID) therapy may
delay the onset of AD. We show that NO-Flurbiprofen (NFP), a novel NSAID that
lacks gastrointestinal side effects, attenuated the neuroinflammatory
reaction and reduced the inflammation-induced memory deficit. Chronic LPS
infusions impaired performance of young rats but not adult or old rats.
Treatment with NFP improved the performance of LPS-infused young rats, but
not LPS-infused adult or old rats. LPS infusions increased the number of
activated microglia in young and adult rats but not old rats. NFP treatment
attenuated the effects of LPS upon microglia activation in young and adult
rats, but not old rats. The results suggest that NSAID therapies designed to
influence the onset of AD should be initiated in adults before age-associated
inflammatory processes within the brain have a chance to develop.
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