Neurotoxicity of Cytokines
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Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice, J Immunol 158(1) :438-45, 1997.
Abstract
- Ali C. Nicole O. Docagne F. Lesne S. MacKenzie ET. Nouvelot A. Buisson A. Vivien D.
Ischemia-induced interleukin-6 as a potential endogenous neuroprotective
cytokine against NMDA receptor-mediated excitotoxicity in the brain, Journal of Cerebral Blood Flow & Metabolism 20(6) :956-66, 2000.
Abstract
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Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes, Mol Psychiatry 3(2) :178-82, 1998.
Abstract
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Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat, Proc Natl Acad Sci U S A 97(10) :5580-5, 2000.
Abstract
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Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury, Stroke. 28(6) :1233-44, 1997.
Abstract
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necrosis factor-induced cytotoxicity. What we do understand and
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Abstract
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Cytokines and cognitive function in mice, Biol Signals Recept 7(1) :45-54, 1998.
Abstract
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Central nervous system toxicity of interferons and other cytokines, J Biol Regul Homeost Agents 2(3) :107-18, 1998 (REF: 157).
Abstract
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glutamate toxicity. Molecular & Cellular Neurosciences. 13(5):379-89, 1999 May.
Abstract
- Brown DR. Dependence of neurones on astrocytes in a coculture system renders neurones
sensitive to transforming growth factor beta1-induced glutamate toxicity.Journal of Neurochemistry. 72(3):943-53, 1999 Mar.
Abstract
- Brugg B; Dubreuil YL; Huber G; Wollman EE; Delhaye-Bouchaud N; Mariani J.
Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain, Proc Natl Acad Sci USA 92(7) :3032-3035, 1995.
Abstract
- Cacabelos R; Alvarez XA; Fernandez-Novoa L; Franco A; Mangues R; Pellicer A; Nishimura T.
Brain interleukin-1 beta in Alzheimer's disease and vascular dementia, Methods Find Exp Clin Pharmacol 16(2) :141-51, 1994.
Abstract
- Campbell IL.
Neuropathogenic actions of cytokines assessed in transgenic mice, Int J Dev Neurosci 13(3-4) :275-84, 1995 (REF: 68).
Abstract
- Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, Gahring LC.
Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways, J Immunol 163(7) :3963-8, 1999.
Abstract
- Cartwright N Demaine A Jahromi M Sanders H Kaminski ER.
A study of cytokine protein secretion, frequencies of cytokine expressing cells and IFN-G gene polymorphisms in
normal individuals, Transplantation 68(10) :1546-52, 1999.
Abstract
- Chao CC. Hu S. Tsang M. Weatherbee J. Molitor TW.
Anderson WR. Peterson PK.Effects of transforming growth factor-beta on murine astrocyte glutamine
synthetase activity. Implications in neuronal injury.Journal of Clinical Investigation. 90(5):1786-93, 1992 Nov.
Abstract
- Chao CC, Hu S, Ehrlich L, Peterson PK.
Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors, Brain Behav Immun 9(4) :355-65, 1995.
Abstract
- Cheng B, Christakos S, Mattson MP.
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis, Neuron 12(1) :139-53, 1994.
Abstract
- de Bock F; Dornand J; Rondouin G.
Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage, Neuroreport 7(6) :1125-9, 1996.
Abstract
- de Bock F, Derijard B, Dornand J, Bockaert J, Rondouin G.
The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF-alpha, Eur J Neurosci 10(10) :3107-14, 1998.
Abstract
- Dickson DW; Lee SC; Mattiace LA; Yen SH; Brosnan C.
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease, Glia 7(1) :75-83, 1993 (REF: 90).
Abstract
- Downen M, Amaral TD, Hua LL, Zhao ML, Lee SC.
Glia 28(2) :114-27, 1999.
Abstract
- Feuerstein GZ; Liu T; Barone FC.
Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha, Cerebrovasc Brain Metab Rev 6(4) :341-60, 1994 (REF: 101).
Abstract
- Fiers W. Tumor necrosis factor. Characterization at
the molecular, cellular and in vivo level. FEBS Letters.
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Abstract
- Floyd RA.
Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development, Free Radic Biol Med 26(9-10) :1346-55, 1999 (REF: 110).
Abstract
- Galasso JM; Wang P; Martin D; Silverstein FS.
Inhibition of TNF-alpha can attenuate or exacerbate excitotoxic injury in neonatal rat brain, Neuroreport 11(2) :231-5, 2000.
Abstract
- Gelbard HA; Dzenko KA; DiLoreto D; del Cerro C; del Cerro M; Epstein LG.
Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis, Dev Neurosci 15(6) :417-22, 1993.
Abstract
- Gimsa U. Peter SV. Lehmann K. Bechmann I. Nitsch R.
Axonal damage induced by invading T cells in organotypic central nervous system tissue in vitro: involvement of microglial cells, Brain Pathology 10(3) :365-77, 2000.
Abstract
- Gitter BD; Cox LM; Rydel RE; May PC.
Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells, Proc Natl Acad Sci U S A 92(23) :10738-41, 1995.
Abstract
- Giulian D, Li J, Leara B, Keenen C.
Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in
culture, Neurochem Int 25(3) :227-33, 1994.
Abstract
- Glabinski A; Krajewski S; Rafalowska J.
Tumor necrosis factor-alpha induced pathology in the rat brain: characterization of stereotaxic injection model, Folia Neuropathol 36(1) :52-62, 1998.
Abstract
- Griffin WS. Sheng JG. Roberts GW. Mrak RE. Interleukin-1 expression in different plaque types in Alzheimer's disease:
significance in plaque evolution.Journal of Neuropathology & Experimental Neurology. 54(2):276-81, 1995 Mar.
Abstract
- Harry GJ.
Cellular indicators of neuronal insult, Crisp Data Base National Institutes Of Health.
Abstract
- Hewett S.
Cytokine mediated enhancement of neuronal injury, Crisp Data Base National Institutes Of Health.
Abstract
- Hong JS.
Roles of brain neuroimmune system in neurodegeneration, Crisp Data Base National Institutes Of Health.
Abstract
- Hull M. Eistetter J. Fiebich BL. Bauer J. Glutamate but not interleukin-6 influences the phosphorylation of tau in
primary rat hippocampal neurons.Neuroscience Letters. 261(1-2):33-6, 1999 Feb 12.
Abstract
- Jeohn GH, Kong LY, Wilson B, Hudson P, Hong JS.
Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia
cultures, J Neuroimmunol 85(1) :1-10, 1998.
Abstract
- Johnstone M; Gearing AJ; Miller KM.
A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced, J Neuroimmunol 93(1-2) :182-93, 1999.
Abstract
- Kalehua AN; Taub DD; Baskar PV; Hengemihle J; Munoz J; Trambadia M; Speer DL; De Simoni MG; Ingram DK.
Aged mice exhibit greater mortality concomitant to increased brain and plasma TNF-alpha levels following intracerebroventricular injection of lipopolysaccharide, Gerontology 46(3) :115-28, 2000.
Abstract
- Kelso A.
The enigma of cytokine redundancy, Immunol Cell Biol 72(1) :97-101, 1994.
Abstract
- Kim J.
Cytokines and adhesion molecules in stroke and related diseases, J Neurol Sci 137(2) :69-78, 1996 (REF: 129).
Abstract
- Kim WG; Mohney RP; Wilson B; Jeohn GH; Liu B; Hong JS.
Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia, J Neurosci 20(16) :6309-16, 2000.
Abstract
- Klegeris A. McGeer E.G. McGeer PL.
Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide (PK 11195) on some mononuclear phagocyte functions.Biochemical Pharmacology. 59(10):1305-1314, 2000 May 15.
Abstract
- Lahiri DK; Nall C.
Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1, Brain Res Mol Brain Res 32(2) :233-40, 1995.
Abstract
- Le WD. Rowe DB. Jankovic J. Xie W. Appel SH.
Effects of cerebrospinal fluid from patients with Parkinson disease on
dopaminergic cells, Archives of Neurology. 56(2) :194-200, 1999.
Abstract
- Lee SC. Liu W. Dickson DW. Brosnan CF. Berman JW.
Cytokine production by human fetal microglia and astrocytes. Differential
induction by lipopolysaccharide and IL-1 beta. Journal of
Immunology. 150(7):2659-67, 1993 Apr 1.
Abstract
- Lemke R; Hartlage-Rubsamen M; Schliebs R.
Differential injury-dependent glial expression of interleukins-1 alpha, beta, and interleukin-6 in rat brain, Glia 27(1) :75-87, 1999.
Abstract
- Licinio J.
Central nervous system cytokines and their relevance for neurotoxicity and apoptosis, J Neural Transm Suppl 49 :169-75, 1997 (REF: 28) Secondary Source ID: Toxbib/97/411448.
Abstract
- Liu XH; Xu H; Barks JD.
Tumor necrosis factor-a attenuates N-methyl-D-aspartate-mediated neurotoxicity in neonatal rat hippocampus, Brain Res 851(1-2) :94-104, 1999.
Abstract
- Luster MI; Simeonova PP; Gallucci R; Matheson J.
Tumor necrosis factor alpha and toxicology, Crit Rev Toxicol 29(5) :491-511, 1999 (REF: 162).
Abstract
- Ma TC; Zhu X.
Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal
neurons, Arzneimittelforschung 50(6) :512-4, 2000.
Abstract
- McCann SM; Licinio J; Wong ML; Yu WH; Karanth S; Rettorri V.
The nitric oxide hypothesis of aging, Exp Gerontol 33(7-8) :813-26, 1998 (REF: 39).
Abstract
- Mehler MF; Marmur R; Gross R; Mabie PC; Zang Z; Papavasiliou A; Kessler JA.
Cytokines regulate the cellular phenotype of developing neural lineage species, Int J Dev Neurosci 13(3-4) :213-40, 1995.
Abstract
- Murray CA; Clements MP; Lynch MA.
Interleukin-1 induces lipid peroxidation and membrane changes in rat hippocampus: An age-related study, Gerontology 45(3) :136-42, 1999.
Abstract
- Orzylowska O. Oderfeld-Nowak B. Zaremba M. Januszewski S. Mossakowski M. Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia.Neuroscience Letters. 263(1):72-6, 1999 Mar 19.
Abstract
- Pellegrini P, Berghella AM, Di Loreto S, Del Beato T, Di Marco F, Adorno D, Casciani CU.
Cytokine contribution to the repair processes and homeostasis recovery following anoxic insult: a possible IFN-gamma-regulating role in IL-1beta neurotoxic action in physiological or damaged CNS, Neuroimmunomodulation 3(4), :213-8, 1996.
Abstract
- Piani D, Spranger M, Frei K, Schaffner A, Fontana A.
Macrophage-induced cytotoxicity of N-methyl-D-aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines, Eur J Immunol 22(9), 1992 :2429-36, 1992.
Abstract
- Prehn JH; Krieglstein J.
Opposing effects of transforming growth factor-beta 1 on glutamate neurotoxicity, Neuroscience 60(1) :7-10, 1994.
Abstract
- Qiu Z. Sweeney DD. Netzeband JG. Gruol DL. Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and
enhances neurotoxicity in developing CNS neurons.Journal of Neuroscience. 18(24):10445-56, 1998 Dec 15.
Abstract
- Rhodin J; Thomas T; Bryant M; Sutton ET.
Animal model of Alzheimer-like vascular pathology and inflammatory reaction, Ann N Y Acad Sci 903 :345-52, 2000.
Abstract
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Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes, Biochem Biophys Res Commun 225(2) :474-8, 1996.
Abstract
- Sheng JG. Ito K. Skinner RD. Mrak RE. Rovnaghi CR. Van
Eldik LJ. Griffin WS.In vivo and in vitro evidence supporting a role for the inflammatory cytokine
interleukin-1 as a driving force in Alzheimer pathogenesis.GNeurobiology of Aging. 17(5):761-6, 1996 Sep-Oct.
Abstract
- Stoll G; Jander S; Schroeter M,
Cytokines in CNS disorders: neurotoxicity versus neuroprotection,
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Abstract
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Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascularcells: the roles of cytokines and CD40, Brain Res 807(1-2) :110-7, 1998.
Abstract
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neuroprotective agent, in Alzheimer disease and vascular dementia.Journal of Clinical Immunology. 19(4):223-30, 1999 Jul.
Abstract
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Abstract
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Hypothalamic interleukin-1 in physiology and pathology, Toxicol Lett 102-103(1998) :295-9, 1998 (REF: 22).
Abstract
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factor-induced interleukin-6 expression and cytotoxicity follow a
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Abstract
Glia Abstract
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Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro, Eur J Neurosci 12(11):3863-3870, 2000.
Abstract
- Wyss-Coray T; Borrow P; Brooker MJ; Mucke L.
Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice, J Neuroimmunol 77(1) :45-50, 1997.
Abstract
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Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide, Nat Med 1(7) :693-9, 1995.
Abstract
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Alzheimer disease. Journal of Neuropathology & Experimental Neurology. 58(6):582-7, 1999 Jun.
Abstract
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