| MSB4d | |
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| Bradford Peercy |
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| University of Maryland, Baltimore County |
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| Title | Long Time Scale cAMP-Dependent Signaling by Protein Kinase A in Pancreatic Beta Cells |
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| Abstract | External signaling to pancreatic beta cells enhances glucose-dependent insulin secretion and biogenesis. This signaling pathway involves the ubiquitous second messenger cyclic adenosine mono-phosphate (cAMP) activation of protein kinase A. Compartmentalization of cAMP appears to be important in cells such as heart cells. Experiments that track the catalytic subunit of PKA (cPKA) during nuclear translocation show success that is dependent on cAMP stimulus profile. We develop both spatial and compartmental models to address cAMP distribution and nuclear translocation of cPKA in response to enhanced production of cAMP or enhanced inhibition of degradation of cAMP. We find that compartmentalization need not play a role in cPKA nuclear translocation and passive transport or rapidly buffering active transport across the nuclear membrane is sufficient to account for many of the observed experiments. |
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| Location | Woodward 4 |
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