Program
| MSD6 | Woodward 6; 10:30 am - 12:30 pm, July 28 |
|---|---|
| Title | Systems approaches in immunology - Part II |
| Organizer | Vitaly Ganusov |
| Los Alamos National Laboratory | |
| Abstract | In the last two decades, we have witnessed a rapidly increasing number of studies applying methods of mathematical modeling in immunology. In part, this was due to the development of several quantitative and powerful techniques of detecting the dynamics of immune responses to pathogens ex vivo and documenting cell dynamics directly in lymphoid tissues in vivo. Immune system is a highly complex with many interacting types of cells and extra-cellular molecules. Understanding how immune system functions and responds to constant pathogen challenges will most likely be limited without a comprehensive, systems approach. There are many different levels at which immune system operates, and to make a complete picture of the immune system, we need to understand processes occurring at these different levels. This mini-symposium is aimed at discussing recent advances in modeling different immunological phenomena on different scales: from intracellular processes to organismal level. Four groups of talks (2 per each) will discuss recent advances in our understanding sub-cellular, cellular, population, and organismal levels of theoretical immunology. Talks will on the details of signalling in T cells, on mechanisms by which magnitude of T cell responses can be controlled, and on the role of T cells in the control of viral infections such as TB and HTLV. |
| Speaker 1 | Steven Kleinstein |
| Yale University, USA | |
| Transcriptional cascades during anti-viral responses in human dendritic cells | |
| Speaker 2 | Francesca Di Rosa |
| Institute of Molecular Biology and Pathology, Consiglio Nazionale delle Ricerche, Rome, Italy | |
| Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on BromodeoxyUridine (BrdU) incorporation in spleen, lymph nodes and bone marrow | |
| Speaker 3 | Jophannes Textor |
| Institute of Theoretical Computer Science, Universität zu Lübeck, Germany | |
| Antigen detection as a distributed randomized search process: A multiscale approach | |
| Speaker 4 | Simenone Marino |
| Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michiga | |
| A multi-compartmental model of Mycobacterium tuberculosis infection in mice: the role of antigen dose in T cell priming |
Link to Part I - MSC6
-- Minisymposium talks are scheduled for 30 min each, including time for questions.