Program
| MSH2 | Friedman 153; 10:15 am - 12:15 pm, July 30 |
|---|---|
| Title | Multiscale modeling of cancer progression |
| Organizer | Yangjin Kim |
| Mathematical Biosciences Institute | |
| Abstract | Cancer is a complex, multiscale process, in which genetic mutations occurring at a sub-cellular level manifest themselves as functional changes at the cellular and tissue scale. The importance of multiscale modeling of tumour cell/microenvironment interactions is currently of great interest. Both the immediate microenvironment (cell-cell or cell-matrix interactions) and the extended microenvironment (e.g. vascular bed) are considered to play crucial roles in tumour progression as well as suppression. Stroma is known to control tumor growth and invasion to surrounding tissue. However, it also prohibits therapeutics from accessing the tumor cells, thus causing drug resistance. Therefore, a thorough understanding of the microenvironment would provide a foundation to generate new strategies in therapeutic drug development. Consequently, 'multiscale/hybrid' mathematical modeling has become an effective, supplementary tool in the quest to understand this complex relationship between tumor cells and host tissue. The goal of this mini-symposium is to bring together researchers working on multiscale modeling in cancer progression and researchers from biology. This session will stimulate biologists who design and perform the specific experiments as well as modelers who are interested in building realistic multiscale/hybrid mathematical models which can improve our understanding of this area. |
| Speaker 1 | Cancelled |
| Speaker 2 | Yangjin Kim |
| Mathematical Biosciences Institute, Ohio State U | |
| A hybrid model of interaction between tumor cells and microenviroment | |
| Speaker 3 | Gargi Chakraborty |
| Department of Pathology, University of Washington | |
| Bridging from Anatomic Imaging to Molecular Imaging through Multi-scale Models for Brain Tumor Growth and Invasion | |
| Speaker 4 | Kasia Rejniak |
| Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, USA | |
| Revealing the Mechanisms Underlying Formation of Carcinomas using the Multiscale IBCell Morphocharts |
-- Minisymposium talks are scheduled for 30 min each, including time for questions.