| Abstract | Hepatitis B is a virus that infects liver cells and leads to either acute or chronic liver disease. The mechanisms responsible for the infection outcome are not well understood, with immune responses being involved in both curing and killing of cells. The formation of cured cells and their role in the infection outcome is studied analytically and validated numerically. Mathematical models for the hepatitis B viral dynamics are developed, and local and global stability analysis of their long term behavior is performed. The models are then fitted to patient data of viral decay following the peak of infection. The results show that viral clearance is only dependent on the strength of the combined killing and curing and independent of the characteristics of the cured cells. |
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