Abstract | The hypothalamus-pituitary-adrenal (HPA) system is closely related to stress and the restoration of homeostasis. In this talk we derive and discuss a novel mathematical model for the HPA system. It is based on three simple rules which constitute a principle of homeostasis and include only substantial physiological elements. In contrast to other models, its main components include, apart from the conventional negative feedback ingredient, a positive feedback loop. To validate the model, we present a parameter estimation procedure which enables one to adapt the model to clinical observations. Furthermore the dynamics of the system is investigated. Finally, the computed parameters may be interpreted from a physiological point of view and thereby gaining connoting insights in diseases like depression, obesity, or diabetes. |