| Abstract | Clinical studies have shown that the combination of cytotoxic therapies and antiangiogenic agents is a more effective strategy in the treatment of malignant tumors than either alone. However, there are different outcomes depending on, at least partially, the drugs used, the delivery vehicle, the dosages of these agents and their treatment schedules. A mathematical model could help in predicting the results of a wide array of possible treatment strategies. In this direction, we have developed a medically relevant model including tumor cells, blood vasculature, interstitial fluid pressure (IFP), as well as proangiogenic and antiangiogenic factors. We discuss the effects of antiangiogenic agents and chemotherapy on tumor growth and its microenvironment. We also compare the efficacy of specific delivery vehicles (e.g. liposomes, nanospehres, etc.) that include single agents or various combinations of treatment with appropriate drug release profiles. |
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