| CTH3f | |
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| Andrew Oster |
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| Mathematical Biosciences Institute |
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| Title | Mitochondrial Calcium Trafficking: excitability, waves, and oscillations |
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| Abstract | Mitochondria have long been known to sequester cytosolic Ca2+ and even to shape intracellular patterns of endoplasmic reticulum -based Ca2+ signaling. Accumulating evidence suggests that the mitochondrial network is an excitable medium which can demonstrate Ca2+ induced Ca2+ release via the mitochondrial permeability transition. The role of this excitability remains unclear, but mitochondrial Ca2+ handling appears to be a crucial element in diverse diseases as diabetes, neurodegeneration and cardiac dysfunction. In this talk, we extend the modular Magnus-Keizer computational model for respiration-driven Ca2+ handling to include a transition pore and we demonstrate both excitability and Ca2+ wave propagation that is accompanied by depolarizations similar to those reported in cell preparations. These waves depend on the energy state of the mitochondria, as well as other elements of mitochondrial physiology. Our results support the concept that mitochondria can transmit state dependent signals about their function in a spatially extended fashion. |
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| Coauthors | Balbir Thomas, David Terman, Christopher P. Fall |
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| Location | Woodward 3 |
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