Program
| MSA4d | |
|---|---|
| David Gurarie | |
| Case Western Reserve University, Cleveland | |
| Title | In-host dynamics of mixed malaria infection with adaptive immunity |
| Abstract | Multiple pathogen species or strains interact within host environment by competing for available resources, and by stimulating cross-reactive immune responses. Such "competition" plays important role for understanding the dynamics of infections, both on individual and community levels. It allows among other to study such evolutionary adaptations, as drug resistance or virulence. We shall outline some basic principles and mathematical approaches to modeling host-parasite interactions with adaptive immunity. Those will be applied to study in-host competition of multi-strain malaria (or malaria-type) pathogens, and its effect on evolution of virulence. |
| Location | Woodward 4 |