| Abstract | We will give an overview of our recent work investigating the influence of incorporating cellular substructure into stochastic reaction-diffusion models of gene regulation and expression. Extensions to the reaction-diffusion master equation and Smoluchowski diffusion limited reaction models that incorporate effects due to the chromatin fiber matrix are introduced. These new mathematical models are then used to study the role of nuclear substructure on the motion of individual proteins and mRNAs within nuclei. |
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