Program
| MSD4b | |
|---|---|
| Mostafa Bachar | |
| Department of Mathematics, King Saud University | |
| Title | Sensitivity analysis of a cardiovascular control system model |
| Abstract | This talk presents a sensitivity analysis of a mathematical model of the cardiovascular control system. The model incorporates sufficient structure and complexity to allow for examining the action of control mechanisms to respond to cardiovascular stresses. The model includes 10 vascular compartments and baroreflex controls to alter resistance, unstressed volume, and heart rate. Total potential number of parameters are 86. The complexity of the model allows for the representation of a variety of modes and sites for control action but at the same time the number of parameters renders the validation with accessible data problematic. Sensitivity identifiability techniques are employed to examine which parameters are mostly likely identifiable for a variety of potential sources of data on the state of the system as well as various testing protocols. The information provided by this analysis allows for a reasonable reduction in parameters to be estimated and can be used to consider which experimental tests might best allow for study of the control response patterns. |
| Location | Woodward 4 |