| Abstract | To better understand the process of carcinogenesis more detailed knowledge of the origin of neoplastic growth is required. In particular we are interested in addressing questions of when the initiated cell begins to show altered behavior and what events lead to tissue deformations and tumors. We investigate these problems using the bio-mechanical models of simple and stratified epithelia, such as mammary breast glands or skin epidermis, due to their unique properties of frequent cell turnover and a finely define topology. We will present an integrated approach combining laboratory experiments and computational modeling showing normal tissue development and turnover, and discuss the possible events (molecular, bio-chemical, mechanical) that lead to disruption of this tightly controlled system and result in the formation of epithelial tumors. |
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