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International Conference on Mathematical Biology and

Annual Meeting of The Society for Mathematical Biology,

July 27-30, 2009

University of British Columbia, Vancouver

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Program

Poster PS01A
Zahra Afsharnezhad
Ferdowsi University of Mashhad-Iran
Title Bifurcation and Permanent DNA Damage Region for P53 Model
Abstract The P53 protein is recently a subject of interest for both mathematicians and biologists. It is known that one of the key players in cancer development is P53, a tumor suppressor. P53 is a transcription factor encoded by a gene whose disruption is associated with approximately 50 to 55 percent of human cancers. In this paper, we stydy bifurcation of the DNA Damage signal for P53 madel which is based on ordinary differential equation model. We show that change of parameters may cause bifurcation switching Damge signal off. Also the region in which the covergence of the DNA Damage signal changes repair to permanent Damage is indicated.
LocationWoodward Lobby (Monday-Tuesday)