Abstract | The P53 protein is recently a subject of interest for both mathematicians and biologists. It is known that one of the key players in cancer development is P53, a tumor suppressor. P53 is a transcription factor encoded by a gene whose disruption is associated with approximately 50 to 55 percent of human cancers. In this paper, we stydy bifurcation of the DNA Damage signal for P53 madel which is based on ordinary differential equation model. We show that change of parameters may cause bifurcation switching Damge signal off. Also the region in which the covergence of the DNA Damage signal changes repair to permanent Damage is indicated. |