Abstract | Deterministic chemical kinetics studied in the past has shown that bistability occurs in systems with strong (cubic) nonlinearity. For certain mesoscopic, weakly nonlinear (quadratic) biochemical reaction systems in a small volume, however, stochasticity can induce bistability and bifurcation that have no macroscopic counterpart. We report the simplest yet known reactions involving driven phosphorylation-dephosphorylation cycle (PdPC) kinetics with autocatalytic kinase. We show that the noise-induced phenomenon is correlated with free energy dissipation thus conform with the open-chemical system theory. |