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International Conference on Mathematical Biology and

Annual Meeting of The Society for Mathematical Biology,

July 27-30, 2009

University of British Columbia, Vancouver

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Program

Poster PS21A
Courtney Davis
University of Utah
Title Mathematically Modeling the Impact of a Population Bottleneck on the Immune Memory Repertoire
Abstract Certain viruses kill off memory T-cells early in infection and thus create lymphopenic conditions in a process called active attrition; following this, memory and naïve T-cells proliferate (and differentiate if necessary) to refill the memory T-cell compartment. I mathematically examine how active attrition and subsequent lymphopenic proliferation impact the memory CD8+ T-cell repertoire using a combination of hypergeometric distributions and Markov birth processes. This gives insight into how the immune memory repertoire changes with infections.
LocationWoodward Lobby (Monday-Tuesday)