| Poster PS22A | |
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| U. Chandimal de Silva |
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| RCC-ERI, Department of Medical Sciences, Ministry of Public Health, Thailand. |
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| Title | Strong positive selection of HIV-1 within host is not reflected in its macro-evolution |
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| Abstract | It has been established that HIV-1 undergoes extensive changes in the genome – particularly in the env region – due to positive selective pressure in the host as well as neutral evolution resulting from erroneous reverse transcription. The major circulating viral population within the host several years after infection would therefore have genetically distanced itself considerably from the initial infecting strain. However, it is doubtful whether these “evolved” viral populations are the major players responsible in the event of infecting a third party, due to differences – phenotypic and genotypic – between viruses from the newly infected and patients from the later stages. Using a model that incorporates evolutionary dynamics at the population level as well as evolution within the host, we provide empirical evidence for the proposition that HIV strains that survive selective evolution and persist in the host as a minority are mainly responsible for infecting a third party. |
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| Coauthors | \"Jiranan Warachit, Nerisa Sattagowit, Chanin Jirapongwattana, Sumolrat Panthong, Piraporn Utachee, Masanori Kameoka, Shota Nakamura, Teruo Yasunaga, Naphatsawan Boonsathorn\" |
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| Location | Woodward Lobby (Monday-Tuesday) |
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