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International Conference on Mathematical Biology and

Annual Meeting of The Society for Mathematical Biology,

July 27-30, 2009

University of British Columbia, Vancouver

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Program

Poster PS35A
Chetan Gadgil
National Chemical Laboratory, Pune, India
Title Exploring robustness of the Drosophila segment polarity network using a Boolean model
Abstract Continuous and Boolean models for the Drosophila segment polarity network have shown that the system is able to maintain the wild-type pattern when subjected to sustained changes in the interaction parameters and initial conditions. Embryo development is likely to occur under fluctuating environmental conditions. We use a well-established Boolean model (Albert and Othmer, 2003) to explore the ability of the segment polarity network to resist transient changes. We identify paths along which alternate unviable states are reached, and hence critical nodes whose state changes lead the system away from the wild-type state. We find that the system appears to be more sensitive to changes that involve activation of normally inactive nodes. Through a simulation of the heat shock response, we show how a localized perturbation in one parasegment is more deleterious than a global perturbation affecting all parasegments. We identify the sequence of events involved in the recovery of the system from a global transient heat shock condition. Finally we discuss these results in terms of the robustness of the system response.
CoauthorsKartik Subramanian
LocationWoodward Lobby (Monday-Tuesday)