| Poster PS39B | |
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| Anthony Sperber |
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| Case Western Reserve University |
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| Title | Hemodynamics, Cerebral Blood Flow, and the BOLD Signal |
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| Abstract | Oxygen delivery to the brain continues to be the focus of active research due to its importance in clinical applications and to the lack of understanding of the mechanisms binding together neuronal activity, energy metabolism, and cerebral blood flow. A better understanding of the interrelation between these phenomena is especially important for the interpretation of functional imaging modalities that are sensitive to blood oxygenation. In particular, BOLD fMRI images are often interpreted directly as maps of brain activity, while the reality may be more subtle. In this work, standard BOLD fMRI models such as the balloon model are revisited and details concerning the oxygen binding of hemoglobin are added. Based on the refined model, the possibility of extracting information concerning the blood oxygenation levels from the time-dependent BOLD signal is investigated by using statistical sampling methods such as particle filtering. |
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| Coauthors | Nicholas Lorenzo, Daniela Calvetti, Erkki Somersalo |
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| Location | Woodward Lobby (Wednesday-Thursday) |
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