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International Conference on Mathematical Biology and

Annual Meeting of The Society for Mathematical Biology,

July 27-30, 2009

University of British Columbia, Vancouver

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Program

Poster PS50B
Hsiu-Ting Tsai
School of Nursing, Chung Shan Medical University, Taichung, Taiwan
Title Glutathione S-transferase Gene Polymorphisms Increase Susceptibility of Hepatocellular Carcinoma among Taiwanese
Abstract BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor to increase the susceptibility of hepatocellular carcinoma. Glutathione S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the roles of these two gene polymorphisms on hepatocellular carcinoma risk and clinicopathological status in Taiwanese. METHODS: Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was used to measure gene polymorphisms in 102 patients with hepatocellular carcinoma and 386 healthy controls. RESULTS: Both gene polymorphisms were not associated with the clinical pathological status of hepatocellular carcinoma and serum expression of liver-related clinical pathological markers. No relationship between GSTM1 gene polymorphism and HCC susceptibility was found. However, in the younger group, age ≤ 56 years old, individuals with GSTT1 present genotype had 2.77 fold risk (95% CI: 1.09-7.09) to have hepatocellular carcinoma compared to null variant after adjustment for other confounders. CONCLUSIONS: GSTT1 present gene polymorphism is considered associated with hepatocellular carcinoma susceptibility in Taiwanese with age ≤ 56 years old.
CoauthorsHsiu-Ting Tsai, Long-Yau Lin, Po-Hui Wang, Shun-Fa Yang
LocationWoodward Lobby (Wednesday-Thursday)