| Abstract | In this work we determine an optimal treatment strategy for hepatitis C virus (HCV) using interferon and ribavirin, through mathematical modeling. We formulate a mathematical model using a system of ordinary differential equations, which describes the interaction of target cells (hepatocytes), infected cells, infectious virions, non-infectious virions, and the two drugs, namely, interferon and ribavirin. Our goal is to minimize the viral load as well as the side effects of treatment. Finally we derive an optimal treatment strategy and then solve it numerically. |
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