| Poster PS57A | |
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| Yangjin Kim |
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| Mathematical Biosciences Institute |
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| Title | Interaction between a tumor and its environment |
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| Abstract | Tumor proliferation depends on its microenvironment. We shall consider two examples. In the first example, we have isolated tumor epithelial cells (TEC) on one side of a membrane and fibroblasts on the other side of the membrane. Cells cannot cross the membrane, but cytokines can cross over. We set up a mathematical model, and then show good fit of the simulation results with experimental results. In the second example, we analyze the migration patterns of glioma cells from the main tumor, and show that the various patterns observed in experiments can be obtained by a model\'s simulations, by choosing appropriate values for some of the parameters of the PDE model; these parameters are the chemotaxis and haptotaxis coefficients, and the cells adhesive forces which act on the migrating cells. |
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| Coauthors | Avner Friedman, Julie Wallace, Fu Li, Michael Ostrowski, Sean Lawler, Michal O. Nowicki, E. Antonio Chiocca |
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| Location | Woodward Lobby (Monday-Tuesday) |
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