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International Conference on Mathematical Biology and

Annual Meeting of The Society for Mathematical Biology,

July 27-30, 2009

University of British Columbia, Vancouver

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Program

Poster PS59B
William Yuen
Harvard University
Title Statistical Inference of Intercellular Interactions in Endothelial Sprouting
Abstract Endothelial sprouting is the first step in angiogenesis, where new blood vessels form from pre-existing vessels. The understanding of the decision process involved in endothelial sprouting is critical in predicting and modulating vascular pattern. In this study, the population statistics of 3D in vitro human microvascular endothelial sprouting are analyzed. Spatial and density distributions of endothelial sprouts suggest that highly concentrated sprout density cannot be accounted for by matrix spatial heterogeneity or intrinsic cell heterogeneity. Rather, the analysis suggests a strong presence of intercellular interactions between endothelial cells in the forms of both activation and inhibition that evidently require Notch signaling.
CoauthorsWilliam Yuen, David Mooney
LocationWoodward Lobby (Wednesday-Thursday)