Program
| MSA5 | Woodward 5; 10:15 am - 12:15 pm, July 27 |
|---|---|
| Title | From Molecules to Sleep: Understanding Circadian Rhythms at Multiple Scales |
| Organizer | Richard Yamada |
| University of Michigan | |
| Abstract | Circadian rhythms are defined as approximately 24 hour cycle in the physiologic processes of most living beings. Experimental evidence indicates that these rhythms play a central role in regulating metabolism, cell cycle control, and depression, amongst many other processes. Mathematical modeling of mammalian circadian rhythms is usually compartmentalized at various scales, beginning with the understanding of individual SCN oscillators ultimately ending with the sleep/wake cycle. These models have their usefulness in their ability to make testable predictions. However, recent interest in this field has shifted towards a more complete and unified understanding of circadian rhythms, including how biochemical processes in SCN cells affects all behavior up to and including the sleep/wake cycle. Questions that are of current interest include: How do we model the interactions between biochemical networks of SCN cells with its electro-physiological properties? How are cells in the SCN network coupled to one another? How can these models of SCN electro-physiology be incorporated into models of sleep? What are some of the computational and mathematical challenges in this area? These questions are not exhaustive, but are meant to give an idea of the questions that will be investigated in this symposium. |
| Speaker 1 | Richard Yamada |
| University of Michigan | |
| Molecular Noise Enhances Oscillations in SCN Network | |
| Speaker 2 | Casey Diekman |
| University of Michigan | |
| Clustering and Temporal Silencing of Electrical Activity in the Suprachiasmatic Nucleus | |
| Speaker 3 | Lisa Rogers |
| Rensselaer Polytechnic Institute | |
| Neurochemically Based Model of the Human Sleep Wake System | |
| Speaker 4 | Badal Joshi |
| Ohio State University/Mathematical Biosciences Institute | |
| Dynamics of Sleep-Wake Cycles: Insights from Development |
-- Minisymposium talks are scheduled for 30 min each, including time for questions.