Program
| MSB2 | Friedman 153; 3:30 pm - 5:30 pm, July 27 |
|---|---|
| Title | Mathematical Models of Molecular Motors |
| Organizer | Richard Yamada |
| University of Michigan | |
| Abstract | Summary: Biomolecular motors are proteins that convert free energy from biochemcial sources into mechanical motion. In recent years, the mathematical modeling of biomolecular motors has gained interest because of the availability of high quality experimental data. The nature of this data allows for the modeling of dynamical processes of these motor proteins, and experimentalists are interested in modeling because of the testable predictions that are made by these quantitative models. Recent examples of biomolecular motors that have been quantitatively modeled include ATP synthase, kinesin, RNA polymerase, helicase, telomerase, and others. Because of the importance of these motors in cell processes from intracellular transport to cell division, there is a pressing need to further develop mathematical and data-analytic techniques (including both analytic and computational approaches) for these systems. Audience: We aim our symposium to the general mathematical biology community, specifically to those mathematicians and experimentalists interested in developing novel applications of mathematics (computational and analytic) to study, model, and understand experimental data from bio-molecular motors. Goals: Our goal is to reach those interested in learning about the research opportunities and questions in this area. We will present the mathematical techniques and methods that are used in this field, methods which can be further developed to study and model the variety of motor proteins in the biological literature. |
| Speaker 1 | Hongyun Wang |
| University of California Santa Cruz | |
| How to convert reciprocal motions to a unidirectional motion? | |
| Speaker 2 | John Fricks |
| Penn State University | |
| The Role of Neck Linker Modification in Kinesin Stepping. | |
| Speaker 3 | Ignacio Rodriguez |
| Courant Institute of Mathematical Sciences | |
| A mathematical model of telomere length regulation and cellular senescence | |
| Speaker 4 | Richard Yamada |
| University of Michigan | |
| Error Correcting Mechanisms During Transcriptional Elongation |
-- Minisymposium talks are scheduled for 30 min each, including time for questions.