Program
| MSB4 | Woodward 4; 3:30 pm - 5:30 pm, July 27 |
|---|---|
| Title | Integrative Aspects of Modeling Beta-cell Signaling |
| Organizers | Bradford Peercy |
| University of Maryland, Baltimore County | |
| Pranay Goel | |
| Indian Institutes of Science Education and Research, Pune | |
| Abstract | Pancreatic beta cells are complicated integrators of both electrical and metabolic signals as well as modulators of these signals. In this minisymposium, we will address several facets of this integration. We will see (1) bifurcation analysis of integrated electrical and glycolytic dynamics from the Dual Oscillator Model centered around calcium; (2) discernment of dynamics that depend on calcium and glucose for vesicular release of insulin; (3) detrimental effects from suboptimal mitochondria function leading to inefficient ATP production and residual production of reactive oxygen species; (4) extracellular signals leading to long term nuclear signaling via cAMP and PKA. These topics not only further understanding of beta cell dynamics but also develop theory potentially useful for other cellular systems. |
| Speaker 1 | Anmar Khadra |
| Laboratory of Biological Modeling -NIDDK/NIH | |
| Investigating the role of IGRP-specific low avidity T cells in the protection against T1D | |
| Speaker 2 | Arthur Sherman |
| Laboratory of Biological Modeling -NIDDK/NIH | |
| The Highly Calcium Sensitive Pool and Newcomer Vesicles: Buy One Get One Free | |
| Speaker 3 | Vipul Periwal |
| Laboratory of Biological Modeling -NIDDK/NIH | |
| Modeling Metabolism in Pancreatic Beta-Cell Mitochondria | |
| Speaker 4 | Bradford Peercy |
| University of Maryland, Baltimore County | |
| Long Time Scale cAMP-Dependent Signaling by Protein Kinase A in Pancreatic Beta Cells |
-- Minisymposium talks are scheduled for 30 min each, including time for questions.