| Abstract | The differential adhesion hypothesis suggests that a mixture of cells will sort by type due to the difference in their adhesiveness. The cellular Potts model was proposed to simulate this behaviour. This model has gained popularity due to its extensibility: the model reproduces many complex biological systems successfully. However, the basic dynamics of the system have gone untested. Cell sorting presupposes motility, and so we remove sorting from the simulation to examine movement by itself. Within a framework of experiments, we test the model response to each parameter. We find that the model is essentially well behaved, although some aspects are unintuitive. We review our findings in the context of biological systems: do the parameters have physical meaning? does the model simulate reality? |
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